首页 » 文章 » 文章详细信息
Scientifica Volume 2020 ,2020-03-31
Serum Level of the Angiotensin-Converting Enzyme in Patients with Idiopathic Acute Optic Neuritis: A Case-Control Study
Clinical Study
Heshmatollah Ghanbari 1 Alireza Dehghani 1 Awat Feizi 2 Arman Amirkhani 1 Mohsen Pourazizi 1
Show affiliations
DOI:10.1155/2020/4867420
Received 2020-01-10, accepted for publication 2020-03-02, Published 2020-03-31
PDF
摘要

Purpose. To evaluate the serum level of angiotensin-converting enzyme (ACE) as an important component of the renin-angiotensin system (RAS) in optic neuritis (ON) compared to the healthy control group in the context investigating the possible role of ACE in ON pathogenesis. Methods. This case-control study was conducted on patients with ON and healthy controls. Serum ACE levels were assessed and compared between the two groups by using commercially available kits by ELISA for ACE. Results. Sixty-five ON patients (75.4% female, mean age 29.70 ± 8.30 years) and 65 controls (75.4% female, mean age 29.66 ± 8.36 years) were enrolled. The median serum ACE levels were 33.5 U/L (range: 25–540) and 26 U/L (range: 22.3–72) for the ON patients and controls, respectively. Serum ACE levels were significantly higher in the patients than in the control group (P65 U/L) was present in 9 (13.8%) patients with ON and 2 (3.1%) controls. Conclusion. Our results indicated that the serum level of ACE appeared to be significantly higher in acute ON than in normal controls.

授权许可

Copyright © 2020 Heshmatollah Ghanbari et al. 2020
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Mohsen Pourazizi.Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran, mui.ac.ir.m.pourazizi@yahoo.com

推荐引用方式

Heshmatollah Ghanbari,Alireza Dehghani,Awat Feizi,Arman Amirkhani,Mohsen Pourazizi. Serum Level of the Angiotensin-Converting Enzyme in Patients with Idiopathic Acute Optic Neuritis: A Case-Control Study. Scientifica ,Vol.2020(2020)

您觉得这篇文章对您有帮助吗?
分享和收藏
0

是否收藏?

参考文献
[1] M. Garg, S. G. Royce, C. Tikellis. (2019). Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?. Gut. DOI: 10.1016/j.survophthal.2019.06.001.
[2] L. Derveaux, M. Demedts, P. Lijnen, A. Amery. et al.(1983). Plasma angiotensin converting enzyme in the diagnosis and monitoring of disease activity in sarcoidosis. European Journal of Respiratory Diseases.64(64):197-206. DOI: 10.1016/j.survophthal.2019.06.001.
[3] H. Yotsumoto. (1982). Longitudinal observations of serum angiotensin-converting enzyme activity in sarcoidosis with and without treatment. Chest.82(5):556-559. DOI: 10.1016/j.survophthal.2019.06.001.
[4] M. H. Levin. (2019). Demyelinating optic neuritis and its subtypes. International Ophthalmology Clinics.59(3):23-37. DOI: 10.1016/j.survophthal.2019.06.001.
[5] M. Platten, S. Youssef, E. M. Hur. (2009). Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1-and TH17-mediated autoimmunity. Proceedings of the National Academy of Sciences.106(35):14948-14953. DOI: 10.1016/j.survophthal.2019.06.001.
[6] R. Schindler, K.-M. Dinarello, K. M. Koch. (1995). Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells. Cytokine.7(6):526-533. DOI: 10.1016/j.survophthal.2019.06.001.
[7] L. J. Balcer. (2006). Optic neuritis. New England Journal of Medicine.354(12):1273-1280. DOI: 10.1016/j.survophthal.2019.06.001.
[8] R. Ranjbar, M. Shafiee, A. Hesari, G. A. Ferns. et al.(2019). The potential therapeutic use of renin-angiotensin system inhibitors in the treatment of inflammatory diseases. Journal of Cellular Physiology.234(3):2277-2295. DOI: 10.1016/j.survophthal.2019.06.001.
[9] R. Deschamps, A. Lecler, C. Lamirel. (2017). Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients. European Journal of Neurology.24(6):875-879. DOI: 10.1016/j.survophthal.2019.06.001.
[10] M. Goto, M. Sasano, M. Fuzisawa, K. Okabe. et al.(1992). Constitutive production of angiotensin converting enzyme from rheumatoid nodule cells under serum free conditions. Annals of the Rheumatic Diseases.51(6):741-742. DOI: 10.1016/j.survophthal.2019.06.001.
[11] J. Lieberman. (1975). Elevation of serum angiotension-converting-enzyme (ACE) level in sarcoidosis. The American Journal of Medicine.59(3):365-372. DOI: 10.1016/j.survophthal.2019.06.001.
[12] C. S. Constantinescu, D. B. P. Goodman, R. I. Grossman, J. A. Mannon. et al.(1997). Serum angiotensin-converting enzyme in multiple sclerosis. Archives of Neurology.54(8):1012-1015. DOI: 10.1016/j.survophthal.2019.06.001.
[13] G. Trinchieri. (1994). Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood.84(12):4008-4027. DOI: 10.1016/j.survophthal.2019.06.001.
[14] J. Culman, A. Blume, T. Gohlke, T. Unger. et al.(2002). The renin-angiotensin system in the brain: possible therapeutic implications for AT1-receptor blockers. Journal of Human Hypertension.16(S3):S64-S70. DOI: 10.1016/j.survophthal.2019.06.001.
[15] R. A. Luke, B. J. Stern, C. J. Krumholz, C. J. Johns. et al.(1987). Neurosarcoidosis: the long-term clinical course. Neurology.37(3):461. DOI: 10.1016/j.survophthal.2019.06.001.
[16] T. Kurihara, Y. Ozawa, S. Ishida, H. Okano. et al.(2012). Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction. International Journal of Inflammation.2012-14. DOI: 10.1016/j.survophthal.2019.06.001.
[17] H. Schweisfurth, S. Schiöberg-Schiegnitz, B. Kuhn, B. Parusel. et al.(1987). Angiotensin I converting enzyme in cerebrospinal fluid of patients with neurological diseases. Klinische Wochenschrift.65(20):955-958. DOI: 10.1016/j.survophthal.2019.06.001.
[18] S. P. Andreoli. (1993). Captopril scavenges hydrogen peroxide and reduces, but does not eliminate, oxidant-induced cell injury. American Journal of Physiology-Renal Physiology.264(1):F120-F127. DOI: 10.1016/j.survophthal.2019.06.001.
[19] M. Mulak, M. Misiuk-Hojlo, M. Slowik. (1999). The behavior of angiotensin-converting enzyme in patients with uveitis. Klinika Oczna.101:5-8. DOI: 10.1016/j.survophthal.2019.06.001.
[20] X. Guo, K. Namekata, A. Kimura, T. Harada. et al.(2017). The renin-angiotensin system regulates neurodegeneration in a mouse model of optic neuritis. The American Journal of Pathology.187(12):2876-2885. DOI: 10.1016/j.survophthal.2019.06.001.
[21] A. Miyazaki, N. Kitaichi, K. Ohgami. (2008). Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats. Graefe’s Archive for Clinical and Experimental Ophthalmology.246(5):747-757. DOI: 10.1016/j.survophthal.2019.06.001.
[22] M. Mogi, J.-M. Li, J. Iwanami. (2006). Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2. Hypertension.48(1):141-148. DOI: 10.1016/j.survophthal.2019.06.001.
[23] J.-M. Li, M. Mogi, K. Tsukuda. (2007). Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2Receptor-interacting protein and src homology 2 domain-containing protein-tyrosine phosphatase 1. Molecular Endocrinology.21(2):499-511. DOI: 10.1016/j.survophthal.2019.06.001.
[24] A. Abel, M. S. McClelland, M. S. Lee. (2019). Critical review: typical and atypical optic neuritis. Survey of Ophthalmology.64(6):770-779. DOI: 10.1016/j.survophthal.2019.06.001.
[25] R. Fukami, S. Ohba, K. Ishida, S. Nakamura. et al.(1994). Serum adenosine deaminase and angiotensin converting enzyme activity in patients with endogenous uveitis. Nippon Ganka Gakkai Zasshi.98:287-292. DOI: 10.1016/j.survophthal.2019.06.001.
[26] M. Takeuchi, K. Oh-i, J. Suzuki. (2006). Elevated serum levels of CXCL9/monokine induced by interferon-γ and CXCL10/interferon--inducible protein-10 in ocular sarcoidosis. Investigative Opthalmology & Visual Science.47(3):1063-1068. DOI: 10.1016/j.survophthal.2019.06.001.
[27] K. Soelberg, S. Jarius, H. Skejoe. (2017). A population-based prospective study of optic neuritis. Multiple Sclerosis Journal.23(14):1893-1901. DOI: 10.1016/j.survophthal.2019.06.001.
[28] J. Stegbauer, D.-H. Lee, S. Seubert. (2009). Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system. Proceedings of the National Academy of Sciences.106(35):14942-14947. DOI: 10.1016/j.survophthal.2019.06.001.
[29] M. R. W. Ehlers, J. F. Riordan. (1989). Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry.28(13):5311-5318. DOI: 10.1016/j.survophthal.2019.06.001.
文献评价指标
浏览 21次
下载全文 1次
评分次数 0次
用户评分 0.0分
分享 0次