首页 » 文章 » 文章详细信息
Evidence-Based Complementary and Alternative Medicine Volume 2020 ,2020-03-30
Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress
Research Article
Rui-rong Chen 1 Juan Liu 1 Zhe Chen 2 Wen-jun Cai 2 Xiu-fen Li 2 , 3 Chuan-li Lu 1 , 3
Show affiliations
DOI:10.1155/2020/9861571
Received 2019-09-30, accepted for publication 2020-02-29, Published 2020-03-30
PDF
摘要

In Southwestern China, the root of Morinda angustifolia Roxb. has been employed as a folk medicine for treating various types of hepatitis and jaundice. The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from M. angustifolia root (AEMA) in carbon tetrachloride- (CCl4-) induced liver injury in mice and identify the main bioactive components. Results indicated that AEMA pretreatment could significantly, in a dose-dependent manner, attenuate the increased levels of ALT and AST in mice serum induced by CCl4. At doses of 100 and 200 mg/kg, AEMA exhibited significant suppression of the elevated hepatic levels of malondialdehyde (MDA), as well as marked upregulatory effects on the activities of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice exposed to CCl4. However, AEMA treatment had no effect on the antioxidant enzyme catalase (CAT) or the nonenzymatic antioxidant glutathione (GSH). Furthermore, two anthraquinone constituents were isolated from AEMA and identified as soranjidiol and rubiadin-3-methyl ether. Soranjidiol exhibited similar protective effects to those of AEMA on liver damage induced by CCl4. Overall, our research clearly demonstrated the hepatoprotective effects of the AEMA, and anthraquinones, particularly soranjidiol, should be considered as the main hepatoprotective principles of M. angustifolia. In addition, the underlying mechanism may be, at least in part, related to its antioxidant properties.

授权许可

Copyright © 2020 Rui-rong Chen et al. 2020
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

1. Xiu-fen Li.College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China, ynau.edu.cn;Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, China, cas.cn.orangexiufen@163.com
2. Chuan-li Lu.Guangdong Key Lab of Sugarcane Improvement & Biorefinery, Guangdong Bioengineering Institute (Guangzhou Sugarcane Industry Research Institute), Guangdong Academy of Sciences, Guangzhou 510316, China, gdas.gd.cn;Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, China, cas.cn.luyixiao-0707@163.com

推荐引用方式

Rui-rong Chen,Juan Liu,Zhe Chen,Wen-jun Cai,Xiu-fen Li,Chuan-li Lu. Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine ,Vol.2020(2020)

您觉得这篇文章对您有帮助吗?
分享和收藏
0

是否收藏?

参考文献
[1] X. Y. Chen, J. Zhang, R. K. Yi. (2018). Hepatoprotective effects of lactobacillus on carbon tetrachloride-induced acute liver injury in mice. International Journal of Molecular Sciences.19(8). DOI: 10.1016/j.fct.2018.01.016.
[2] M.-Y. Wang, G. Anderson, D. Nowicki, J. Jensen. et al.(2008). Hepatic protection by noni fruit juice against CCl4-induced chronic liver damage in female SD rats. Plant Foods for Human Nutrition.63(3):141-145. DOI: 10.1016/j.fct.2018.01.016.
[3] T. Bu, C. Wang, Q. Meng. (2018). Hepatoprotective effect of rhein against methotrexate-induced liver toxicity. European Journal of Pharmacology.834:266-273. DOI: 10.1016/j.fct.2018.01.016.
[4] D. Borpujari, T. C. Dutta. (2015). Ethnomedicinal and aromatic plants use to health care and cooking purposes by the Singphoo Tribes of Tinsukia District of Assam, India. International Journal of Scientific and Research Publications.5(4):1-3. DOI: 10.1016/j.fct.2018.01.016.
[5] B. Ranjana, C. N. Saikia. (2005). Isolation of colour components from native dye-bearing plants in northeastern India. Bioresource Technology.96(3):363-372. DOI: 10.1016/j.fct.2018.01.016.
[6] J. Sun, X. Wen, J. Liu. (2018). Protective effect of an arabinogalactan from black soybean against carbon tetrachloride-induced acute liver injury in mice. International Journal of Biological Macromolecules.117:659-664. DOI: 10.1016/j.fct.2018.01.016.
[7] V. Tzankova, D. Aluani, M. Kondeva-Burdina. (2017). Hepatoprotective and antioxidant activity of quercetin loaded chitosan/alginate particles in vitro and in vivo in a model of paracetamol-induced toxicity. Biomedicine & Pharmacotherapy.92:569-579. DOI: 10.1016/j.fct.2018.01.016.
[8] K. M. Naji, E. S. Al-Shaibani, F. A. Alhadi, S. A. Al-Soudi. et al.(2017). Hepatoprotective and anti-oxidant effects of single clove garlic against CCl-induced hepatic damage in rabbits. BMC Complementary and Alternative Medicine.17. DOI: 10.1016/j.fct.2018.01.016.
[9] P. Sherovski, G. Stojković, N. Ristovska. (2018). Development, validation and application of first derivative spectroscopy ratio method for estimation of Bradford assay. Analytical Biochemistry.558:35-40. DOI: 10.1016/j.fct.2018.01.016.
[10] K. Srithi, H. Balslev, P. Wangpakapattanawong, P. Srisanga. et al.(2009). Medicinal plant knowledge and its erosion among the Mien (Yao) in northern Thailand. Journal of Ethnopharmacology.123(2):335-342. DOI: 10.1016/j.fct.2018.01.016.
[11] W. Liu, T. Hou, W. Shi, D. Guo. et al.(2018). Hepatoprotective effects of selenium-biofortified soybean peptides on liver fibrosis induced by tetrachloromethane. Journal of Functional Foods.50:183-191. DOI: 10.1016/j.fct.2018.01.016.
[12] G. Surendiran, N. Mathivanan. (2011). Hepatoprotective properties of J.E. Smith ( Roxb.) fruit extract. Medicinal Chemistry Research.20(3):307-313. DOI: 10.1016/j.fct.2018.01.016.
[13] J. Xie, W. Wang, C. Dong. (2018). Protective effect of flavonoids from leaves against carbon tetrachloride-induced acute liver injury in mice. Food and Chemical Toxicology.119:392-399. DOI: 10.1016/j.fct.2018.01.016.
[14] Y. A. Lee, M. C. Wallace, S. L. Friedman. (2015). Pathobiology of liver fibrosis: a translational success story. Gut.64(5):830-841. DOI: 10.1016/j.fct.2018.01.016.
[15] M. C. Lampi, C. A. Reinhart-King. (2018). Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials. Science Translational Medicine.10(422):14. DOI: 10.1016/j.fct.2018.01.016.
[16] C. T. Wu, J. S. Deng, W. C. Huang. (2019). Salvianolic acid C against acetaminophen-induced acute liver injury by attenuating inflammation, oxidative stress, and apoptosis through inhibition of the keap1/Nrf2/HO-1 signaling. Oxidative Medicine and Cellular Longevity.2019:13. DOI: 10.1016/j.fct.2018.01.016.
[17] B. Islam, A. Karim, M. M. Chowdhury, S. Bhattacharjee. et al.(2015). Evaluation of membrane stabilization and thrombolytic activities of Roxb. Der Pharmcia Sinica.6(8):40-44. DOI: 10.1016/j.fct.2018.01.016.
[18] Y. Sun, X. Yang, X. Lu, D. Wang. et al.(2013). Protective effects of Keemun black tea polysaccharides on acute carbon tetrachloride-caused oxidative hepatotoxicity in mice. Food and Chemical Toxicology.58:184-192. DOI: 10.1016/j.fct.2018.01.016.
[19] P. P. Adhikari, S. Talukdar, A. Borah. (2018). Ethnomedicobotanical study of indigenous knowledge on medicinal plants used for the treatment of reproductive problems in Nalbari district, Assam, India. Journal of Ethnopharmacology.210:386-407. DOI: 10.1016/j.fct.2018.01.016.
[20] X. Bian, X. Liu, J. Liu. (2019). Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-B and activating Nrf2/HO-1 signaling pathways. Journal of the Science of Food and Agriculture.99(7):3283-3290. DOI: 10.1016/j.fct.2018.01.016.
[21] M. A. Zamzami, O. A. S. Baothman, F. Samy, M. K. Abo-Golayel. et al.(2019). Amelioration of CCl4-Induced Hepatotoxicity in Rabbits by Lepidium Sativum Seed. Evidence-Based Complementary and Alternative Medicine.2019:13. DOI: 10.1016/j.fct.2018.01.016.
[22] T. Chen, C. M. Taylor. (2008). Morinda linnaeus. Floria of China.19:221-222. DOI: 10.1016/j.fct.2018.01.016.
[23] H. Zhao, E. Biehl. (1995). Preparation of naturally occurring anthraquinones using the aryne reaction. Journal of Natural Products.58(12):1970-1974. DOI: 10.1016/j.fct.2018.01.016.
[24] W. Wang, L. Jiang, Y. Ren, M. Shen. et al.(2019). Characterizations and hepatoprotective effect of polysaccharides from Mesona blumes against tetrachloride-induced acute liver injury in mice. International Journal of Biological Macromolecules.124:788-795. DOI: 10.1016/j.fct.2018.01.016.
[25] H. X. Dao, Y. F. Lin, Y. H. Zhao, R. L. Liao. et al.(2011). A review of common used medicinal plants and prescriptions used in Dai Minority for treating biliousness. Journal of Medicine & Pharmacy of Chinese Minorities.17(2):41-43. DOI: 10.1016/j.fct.2018.01.016.
[26] B. Islam, S. M. Tareq, S. Bhattacharjee, S. Shahadat. et al.(2015). In-vivo antipyretic activity of methanolic extracts of root and leaves of Roxb. IOSR Journal of Pharmacy.5(6):15-17. DOI: 10.1016/j.fct.2018.01.016.
[27] S. C. N. Montoya, A. M. Agnese, J. L. Cabrera. (2006). Anthraquinone derivatives from. Journal of Natural Products.69(5):801-803. DOI: 10.1016/j.fct.2018.01.016.
[28] C. Peng, Z. M. Zhou, J. Li. (2019). CCl-induced liver injury was ameliorated by Qi-Ge decoction through the antioxidant pathway. Evidence-Based Complementary and Alternative Medicine.2019:18. DOI: 10.1016/j.fct.2018.01.016.
[29] N. Bencheikh, M. Bouhrim, L. Kharchoufa, M. Choukri. et al.(2019). Protective effect of L. (Desf.) fruit against CCl-induced acute liver injury in rat. Evidence-Based Complementary and Alternative Medicine.2019:10. DOI: 10.1016/j.fct.2018.01.016.
[30] A. A. Shahat, R. Ullah, A. S. Alqahtani, M. S. Alsaid. et al.(2018). Hepatoprotective effect of leaf extract and its various fractions against carbo tetra chloride induced hepatotoxicity in rats. Evidence-Based Complementary and Alternative Medicine.2018:9. DOI: 10.1016/j.fct.2018.01.016.
[31] A. Raskocis, N. Bukumirovic, M. P. Kusturica. (2018). Hepatoprotective and antioxidant potential of pycnogenol in acetaminophen-induced hepatotoxicity in rats. Phytotherapy Research.33(3):631-639. DOI: 10.1016/j.fct.2018.01.016.
[32] Y. Ding, P. Liu, Z. L. Chen. (2018). Emodin attenuates lipopolysaccharide-induced acute liver injury via inhibiting the TLR4 signaling pathway in vitro and in vivo. Frontiers in Pharmacology.9:16. DOI: 10.1016/j.fct.2018.01.016.
[33] Y. L. Peng, H. Y. Zeng, Z. P. Huang. (2008). Ethnomedicinal study on the therapies and folk medicines used in Dai Minority for prevention and treatment for liver and gall diseases. Journal of Medicine & Pharmacy of Chinese Minorities.14(2):39-41. DOI: 10.1016/j.fct.2018.01.016.
[34] W. Jiang, R. Zhou, P. Li. (2016). Protective effect of chrysophanol on LPS/d-GalN-induced hepatic injury through the RIP140/NF-B pathway. RSC Advances.6(44):38192-38200. DOI: 10.1016/j.fct.2018.01.016.
[35] W. Xiang, Q. S. Song, H. J. Zhang, S. P. Guo. et al.(2008). Antimicrobial anthraquinones from. Fitoterapia.79(7-8):501-504. DOI: 10.1016/j.fct.2018.01.016.
[36] J. J. Liu, D. D. Luo, Y. L. Wu. (2019). The protective effect of fruit extract on acetaminophen-induced liver injury in mice. Evidence-Based Complementary and Alternative Medicine.2019:13. DOI: 10.1016/j.fct.2018.01.016.
[37] R. Bhuyan, D. C. Saikia, C. N. Saikai. (2002). Isolation of colour component from the roots of Roxb. and evaluation of its dyeing characteristics. Indian Journal of Fibre & Textile Research.27:429-433. DOI: 10.1016/j.fct.2018.01.016.
文献评价指标
浏览 101次
下载全文 6次
评分次数 0次
用户评分 0.0分
分享 0次