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Evidence-Based Complementary and Alternative Medicine Volume 2020 ,2020-03-30
Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress
Research Article
Rui-rong Chen 1 Juan Liu 1 Zhe Chen 2 Wen-jun Cai 2 Xiu-fen Li 2 , 3 Chuan-li Lu 1 , 3
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Received 2019-09-30, accepted for publication 2020-02-29, Published 2020-03-30

In Southwestern China, the root of Morinda angustifolia Roxb. has been employed as a folk medicine for treating various types of hepatitis and jaundice. The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from M. angustifolia root (AEMA) in carbon tetrachloride- (CCl4-) induced liver injury in mice and identify the main bioactive components. Results indicated that AEMA pretreatment could significantly, in a dose-dependent manner, attenuate the increased levels of ALT and AST in mice serum induced by CCl4. At doses of 100 and 200 mg/kg, AEMA exhibited significant suppression of the elevated hepatic levels of malondialdehyde (MDA), as well as marked upregulatory effects on the activities of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice exposed to CCl4. However, AEMA treatment had no effect on the antioxidant enzyme catalase (CAT) or the nonenzymatic antioxidant glutathione (GSH). Furthermore, two anthraquinone constituents were isolated from AEMA and identified as soranjidiol and rubiadin-3-methyl ether. Soranjidiol exhibited similar protective effects to those of AEMA on liver damage induced by CCl4. Overall, our research clearly demonstrated the hepatoprotective effects of the AEMA, and anthraquinones, particularly soranjidiol, should be considered as the main hepatoprotective principles of M. angustifolia. In addition, the underlying mechanism may be, at least in part, related to its antioxidant properties.


Copyright © 2020 Rui-rong Chen et al. 2020
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


1. Xiu-fen Li.College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China, ynau.edu.cn;Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, China, cas.cn.orangexiufen@163.com
2. Chuan-li Lu.Guangdong Key Lab of Sugarcane Improvement & Biorefinery, Guangdong Bioengineering Institute (Guangzhou Sugarcane Industry Research Institute), Guangdong Academy of Sciences, Guangzhou 510316, China, gdas.gd.cn;Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, China, cas.cn.luyixiao-0707@163.com


Rui-rong Chen,Juan Liu,Zhe Chen,Wen-jun Cai,Xiu-fen Li,Chuan-li Lu. Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine ,Vol.2020(2020)



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