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International Journal of Endocrinology Volume 2019 ,2019-09-19
The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population
Research Article
Ider Oujamaa 1 Majda Sebbani 2 Lahcen Elmoumou 1 Aïcha Bourrahouate 3 Rabiy El Qadiry 3 Soufian El Moussaoui 3 Imane Ait Sab 3 Mohamed Sbihi 3 Laila Ennazk 4 Ghizlane El Mghari-Tabib 4 Nawal El Ansari 4 Hicham Baizri 5 Mohamed Amine 2 Brahim Admou 1 , 6
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DOI:10.1155/2019/7895207
Received 2019-02-28, accepted for publication 2019-08-13, Published 2019-08-13
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摘要

Objective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. The screening for CD was performed by an Elisa IgA anti-tissue transglutaminase antibody (tTGA) testing, combined with IgA quantification by nephelometry. Positive-IgA-tTGA cases were secondly tested for anti-endomysial antibodies (EMA) using an immunofluorescence technique, and the IgA deficiency cases were screened for IgG-tTGA. Patients with low positive tTGA titers underwent HLA-DQ2/DQ8 typing. Sociodemographic and clinical data of the patients were collected using a hetero-administered questionnaire. The comparison of clinical and biological data between seropositive and seronegative diabetics was done using independent T, Mann–Whitney U, chi-squared, and Fisher tests, which were considered significant if p value <0.05. Results. The prevalence of CD-specific auto-antibodies was estimated to be 9.1% (IC = 95%), with 25 positive cases in tTGA and EMA testing. Eight cases displayed low titers of IgA-tTGA, among which 4 were positive for HLA-DQ2, 1 for HLA-DQ8, and 1 for both DQ2 and DQ8. The other 2 cases had a biopsy-proven CD. Compared to seronegative patients, seropositive cases had a higher percentage of associated autoimmune disorders (16% vs. 2.4%, p=0.008), with a significant lower height Z-scores (median: −0.90 (−3.93 to 0.95) vs. −0.51 (−4.54 to 2.18), p=0.029) and a higher HbA1c level (median: 11.30% (7.31 to 16.00) vs. 9.30% (4.40 to17.31), p=0.022). Conclusion. The current study gave evidence of a high prevalence of CD specific auto-antibodies in T1D population. The co-existence of these two conditions was associated with a poor glycemic control, a lower height, and other autoimmune diseases. These findings may suggest the necessity of a systematic screening of CD in T1D patients.

授权许可

Copyright © 2019 Ider Oujamaa et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Brahim Admou.Laboratory of Immunology, University Hospital of Marrakech, Marrakech, Morocco, upm.ac.ma;ERCIM Research Team, Faculty of Medecine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco, uca.ma.br.admou@uca.ac.ma

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Ider Oujamaa,Majda Sebbani,Lahcen Elmoumou,Aïcha Bourrahouate,Rabiy El Qadiry,Soufian El Moussaoui,Imane Ait Sab,Mohamed Sbihi,Laila Ennazk,Ghizlane El Mghari-Tabib,Nawal El Ansari,Hicham Baizri,Mohamed Amine,Brahim Admou. The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population. International Journal of Endocrinology ,Vol.2019(2019)

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