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Journal of Oncology Volume 2019 ,2019-09-26
IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis
Research Article
María del Carmen Lagunas-Cruz 1 Arturo Valle-Mendiola 1 Jonathan Trejo-Huerta 1 Leticia Rocha-Zavaleta 2 María de Lourdes Mora-García 1 Adriana Gutiérrez-Hoya 1 , 3 Benny Weiss-Steider 1 Isabel Soto-Cruz 1
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DOI:10.1155/2019/7475295
Received 2019-03-23, accepted for publication 2019-08-04, Published 2019-08-04
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摘要

Interleukin 2 (IL-2) has been used for the treatment of different types of cancer that express the IL-2 receptor (IL-2R). However, the effect of IL-2 on cervical cancer cells is unknown. IL-2R is present in normal cells of the immune system but not in the healthy cervix. We report that IL-2R is expressed in cervical cancer cells. IL-2 decreases cervical cancer cell proliferation via transient arrest of the G1 phase, which does not result in apoptosis or senescence. IL-2 upregulates the expression of p53 and p21 and downregulates cyclin D. In addition, we report the resistance of cervical cancer cells to treatments that induce apoptosis in HeLa and INBL cells. When arrested cells were treated with cisplatin, the cytokine protected cells from apoptosis induced by cisplatin. The effects of IL-2 on the cell cycle do not induce cellular senescence or activate the proapoptotic protein Bax. The cell arrest induced by IL-2 is conferring protection to cells against apoptosis.

授权许可

Copyright © 2019 María del Carmen Lagunas-Cruz et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Isabel Soto-Cruz.Molecular Oncology Laboratory, Cell Differentiation and Cancer Research Unit, FES Zaragoza, National University of Mexico, Batalla 5 de Mayo S/n Col. Ejército de Oriente, CP 09230 Mexico City, Mexico, unam.mx.sotocruz@unam.mx

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María del Carmen Lagunas-Cruz,Arturo Valle-Mendiola,Jonathan Trejo-Huerta,Leticia Rocha-Zavaleta,María de Lourdes Mora-García,Adriana Gutiérrez-Hoya,Benny Weiss-Steider,Isabel Soto-Cruz. IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis. Journal of Oncology ,Vol.2019(2019)

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