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BioMed Research International Volume 2019 ,2019-07-24
Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
Review Article
Zhongjing Lin 1 Shouyue Huang 1 Jun Sun 1 Bing Xie 1 Yisheng Zhong 1
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DOI:10.1155/2019/6707650
Received 2019-01-30, accepted for publication 2019-07-14, Published 2019-07-14
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摘要

Background. Previous studies exploring the association between toll-like receptor 4 (TLR4) polymorphisms and open angle glaucoma (OAG) presented inconsistent results. We aimed to investigate the association between TLR4 polymorphisms and OAG. Methods. A systematic literature search was conducted in PubMed, EMBASE, ISI Web of Knowledge, and the Cochrane Library up to 31 December 2018. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated, followed by stratification analyses according to ethnicity and glaucoma subtype. Results. TLR4 rs7037117 polymorphism had significant associations with increased risk of OAG in allelic model (OR=1.25; 95%CI: 1.09-1.44; P=0.002) and recessive model (OR=1.49; 95%CI: 1.08-2.04; P=0.01). With regard to rs10759930, rs12377632, and rs2149356, the results showed significant increased risks in all genetic models (all P0.05). Furthermore, the association of rs1927911 with OAG risk was found to be significant in recessive model (OR=1.34; 95%CI: 1.06-1.71; P=0.02). As for rs4986790 and rs4986791, meta-analyses were not performed due to the limited number of studies and the ethnic differences. Subgroup analysis indicated that the above polymorphisms with significant differences might increase the susceptibility in POAG patients. As for the ethnicity, rs7037117, rs10759930, and rs1927911 might increase the risk in Asians, while rs12377632 and rs2149356 might increase the risk in Asians and Mexicans. Conclusion. The meta-analysis highlighted that certain mutations of some TLR4 polymorphisms might increase the susceptibility of OAG. However, TLR4 polymorphisms are still far from being candidate genetic biomarkers for OAG. Additional researches involving larger scale epidemiological studies are warranted to validate our results.

授权许可

Copyright © 2019 Zhongjing Lin et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

1. Bing Xie.Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, 200025 Shanghai, China, sjtu.edu.cn.brinkleybing@126.com
2. Yisheng Zhong.Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, 200025 Shanghai, China, sjtu.edu.cn.yszhong68@126.com

推荐引用方式

Zhongjing Lin,Shouyue Huang,Jun Sun,Bing Xie,Yisheng Zhong. Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis. BioMed Research International ,Vol.2019(2019)

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