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BioMed Research International Volume 2019 ,2019-07-25
The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis
Review Article
Rong Li 1 Yanqing Liu 1 Tong Xu 1 Haijiao Zhao 1 Jingya Hou 1 Yun Wu 1 Dongmei Zhang 1 , 2
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DOI:10.1155/2019/2587245
Received 2019-05-31, accepted for publication 2019-07-09, Published 2019-07-09
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摘要

Background. To improve the efficacy of regenerative treatment for gingival recessions, the autologous platelet concentrates (APCs) combined with coronally advanced flap (CAF) have been investigated. However, few studies systematically assess the complementary effect of APCs in periodontal regeneration. The present study aims to evaluate the additional effect of different types of APCs to CAF in the treatment of gingival recessions. Methods. Electronic databases (EMBASE, MEDLINE, and Cochrane Central Register of Controlled Trails) and relevant journals were searched until May 15, 2019. Only randomized controlled trials (RCTs) in English were included. Outcome variables include root coverage (RC), recession depth (RD), clinical attachment level (CAL), keratinized tissue width (KTW), and gingival thickness (GT). Data were analyzed with Revman5.3. The estimate of effect sizes was expressed as the mean differences and the 95% confidence interval. Results. 8 RCTs involving 170 patients (328 sites) were included. Our meta-analysis indicated RC, RD, CAL, KTW, and GT were better improved in the CAF plus APCs groups than the CAF alone. The subgroup analyses revealed that platelet-rich fibrin (PRF) brought significant improvement in RC, RD, CAL, and GT. Concentrated growth factors (CGF) lead clinic beneficial in CAL, KTW, and GT. No significant effect of platelet-rich plasma (PRP) could be found in any clinical parameters when combined with CAF. Conclusions. PRF could exert additional effect to CAF; the preferred treatment for gingival recessions was considered. Based on the limited studies, it seemed that PRP failed to show any additional effect and it was not suggested for gingival recessions. Given the limited research and high risk of bias, it is still needed to confirm the additional effect of CGF by more high-quality studies.

授权许可

Copyright © 2019 Rong Li et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Dongmei Zhang.Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China, cmu.edu.cn;Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China, cmu.edu.cn.juliyia@163.com

推荐引用方式

Rong Li,Yanqing Liu,Tong Xu,Haijiao Zhao,Jingya Hou,Yun Wu,Dongmei Zhang. The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis. BioMed Research International ,Vol.2019(2019)

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