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International Journal of Polymer Science Volume 2019 ,2019-07-14
Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis
Research Article
Gongbiao Lu 1 Lin Du 2 Jishou Lu 1 Liuzhong Jin 1
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Received 2019-03-18, accepted for publication 2019-06-28, Published 2019-06-28

The pathogeny of osteoarthritis (OA) is very complicated and still is one of the difficulties in a treating procedure. Here, we constructed nanoparticles using hyaluronan acid (HA) and astragalus polysaccharides (APS) for OA therapy. We assessed OA biomarkers and IL-1β-induced matrix metalloproteinase (MMP) expressions. Nanoparticles of 100 nm showed high drug loading of 28.6% (w/w) and extended drug release of 59% over 1 month. Our results demonstrated that nano treatment significantly improved IL-1β-induced cell viability of chondrocytes. Induction of MMP-9, MMP-13, and TNF-α was alleviated by nanoparticles. Furthermore, nano elevated the expression of osteopontin (OPN) and attenuated inducible nitric oxide synthase (iNOS) protein. Our data indicated the protective role of HA and APS-capsuled nanoparticles in OA treatment.


Copyright © 2019 Gongbiao Lu et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liuzhong Jin.Department of Spine Surgery, Jining No. 1 People’s Hospital, Jining, Shandong 272011, China, jnrmyy.com.13455580113@163.com


Gongbiao Lu,Lin Du,Jishou Lu,Liuzhong Jin. Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis. International Journal of Polymer Science ,Vol.2019(2019)



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