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Case Reports in Infectious Diseases Volume 2019 ,2019-07-14
Brucella Periprosthetic Joint Infection Involving Bilateral Knees with Negative Synovial Fluid Alpha-Defensin
Case Report
Abdullah Balkhair 1 Sultan Al Maskari 2 Shadin Ibrahim 1 Ibrahim Al Busaidi 1 Mohammed Al Amin 1 Hashim Ba Taher 1
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DOI:10.1155/2019/9423946
Received 2019-05-03, accepted for publication 2019-06-17, Published 2019-06-17
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摘要

Periprosthetic joint infection (PJI) due to Brucella is uncommon despite relatively high endemicity of human brucellosis and its osteoarticular predilection. We report a case of a 57-year-old woman with bacteraemic brucellosis complicated by Brucella periprosthetic infection of both knee joints occurring a decade after bilateral knee arthroplasty and associated with a negative synovial fluid alpha-defensin test. The patient was successfully treated with anti-Brucella therapy alone and without surgical revision, resulting in clinical and microbiological cure. We propose that Brucella should be considered as a possible cause of prosthetic joint infection in the appropriate clinical and epidemiological settings. A negative synovial fluid alpha-defensin (Synovasure AD test) should not be used as a rule-out test for Brucella PJI. Brucella PJI without radiological loosening may be treated conservatively and solely with antimicrobial therapy.

授权许可

Copyright © 2019 Abdullah Balkhair et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Abdullah Balkhair.Department of Medicine, Infectious Diseases Unit, Sultan Qaboos University Hospital, P.O. Box. 35, Al koudh. 123, Muscat, Oman, squh.edu.om.balkhair2020@gmail.com

推荐引用方式

Abdullah Balkhair,Sultan Al Maskari,Shadin Ibrahim,Ibrahim Al Busaidi,Mohammed Al Amin,Hashim Ba Taher. Brucella Periprosthetic Joint Infection Involving Bilateral Knees with Negative Synovial Fluid Alpha-Defensin. Case Reports in Infectious Diseases ,Vol.2019(2019)

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