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BioMed Research International Volume 2019 ,2019-07-14
The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Review Article
Shanshan Zhu 1 Yuhui Wang 2 Fei Luo 1 Jie Liu 1 Liangchang Xiu 1 Jiheng Qin 3 Tao Wang 2 Na Yu 2 Hongfu Wu 4 Tangbin Zou 1
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DOI:10.1155/2019/7643542
Received 2018-11-12, accepted for publication 2019-04-28, Published 2019-04-28
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摘要

Background. The relationship between vitamin D level and NAFLD has not been investigated in children and adolescents. We performed a meta-analysis of published observational studies to assess this association between vitamin D levels (measured as serum 25-hydroxy vitamin D [25(OH)D]) and NAFLD in this age group. Methods. Relevant studies conducted before May 20, 2018, were identified from the following electronic databases: PubMed, the Cochrane Library, Embase, and the Chinese CNKI databases. The quality of the included studies was evaluated using the Newcastle Ottawa Scale, and associations between vitamin D levels and NAFLD were estimated using standardised mean differences (SMD) and 95% confidence interval (CI). Subgroup and sensitivity analysis were used to identify sources of heterogeneity, and publication bias was evaluated using funnel plots. Results. Eight articles were included in this meta-analysis. A significant difference was observed between low 25(OH)D levels and NAFLD in children and adolescents (SMD = -0.59, 95%CI = -0.98, -0.20, P <  0.01). Subgroup analysis revealed no differences in the study type, geographic location, BMI, and age subgroups. Conclusions. Low vitamin D levels were associated with NAFLD in children and adolescents.

授权许可

Copyright © 2019 Shanshan Zhu et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

1. Hongfu Wu.School of Basic Medical Sciences, Guangdong Medical University, Dongguan 523808, China, gdmu.edu.cn.hongfuw@126.com
2. Tangbin Zou.Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China, gdmu.edu.cn.zoutb@163.com

推荐引用方式

Shanshan Zhu,Yuhui Wang,Fei Luo,Jie Liu,Liangchang Xiu,Jiheng Qin,Tao Wang,Na Yu,Hongfu Wu,Tangbin Zou. The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis. BioMed Research International ,Vol.2019(2019)

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