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Evidence-Based Complementary and Alternative Medicine Volume 2019 ,2019-07-11
Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases
Review Article
Hsiang-Chun Lai 1 Qwang-Yuen Chang 2 Ching-Liang Hsieh 1 , 3 , 4 , 5
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DOI:10.1155/2019/2909632
Received 2019-04-25, accepted for publication 2019-06-23, Published 2019-06-23
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摘要

In this article, we review signal transduction pathways through which acupuncture treats nervous system diseases. We electronically searched the databases, including PubMed, MEDLINE, clinical Key, the Cochrane Library, and the China National Knowledge Infrastructure from their inception to December 2018 using the following MeSH headings and keywords alone or in varied combination: acupuncture, molecular, signal transduction, genetic, cerebral ischemic injury, cerebral hemorrhagic injury, stroke, epilepsy, seizure, depression, Alzheimer’s disease, dementia, vascular dementia, and Parkinson’s disease. Acupuncture treats nervous system diseases by increasing the brain-derived neurotrophic factor level and involves multiple signal pathways, including p38 MAPKs, Raf/MAPK/ERK 1/2, TLR4/ERK, PI3K/AKT, AC/cAMP/PKA, ASK1-JNK/p38, and downstream CREB, JNK, m-TOR, NF-κB, and Bcl-2/Bax balance. Acupuncture affects synaptic plasticity, causes an increase in neurotrophic factors, and results in neuroprotection, cell proliferation, antiapoptosis, antioxidant activity, anti-inflammation, and maintenance of the blood-brain barrier.

授权许可

Copyright © 2019 Hsiang-Chun Lai et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Ching-Liang Hsieh.Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan, cmu.edu.tw;Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan, cmu.edu.cn;Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 40402, Taiwan, cmu.edu.tw;Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan, cmu.edu.tw.clhsieh@mail.cmuh.org.tw

推荐引用方式

Hsiang-Chun Lai,Qwang-Yuen Chang,Ching-Liang Hsieh. Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases. Evidence-Based Complementary and Alternative Medicine ,Vol.2019(2019)

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