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BioMed Research International Volume 2019 ,2019-07-02
Levels of Myeloperoxidase and Metalloproteinase-9 in Gingival Crevicular Fluid from Diabetic Subjects with and without Stage 2, Grade B Periodontitis
Research Article
Diana C. Peniche-Palma 1 Bertha A. Carrillo-Avila 1 Eduardo A. Sauri-Esquivel 1 Karla Acosta-Viana 2 Vicente Esparza-Villalpando 3 Amaury Pozos-Guillen 3 Marcela Hernandez-Rios 4 Victor M. Martinez-Aguilar 1 , 3
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DOI:10.1155/2019/5613514
Received 2019-05-18, accepted for publication 2019-05-29, Published 2019-05-29
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摘要

Objective. The present study aimed to compare levels of matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) in gingival crevicular fluid (GCF) from subjects with controlled and noncontrolled Type 2 Diabetes Mellitus (T2D), with and without stage 2 grade B periodontitis (POD2B) versus healthy (H) subjects. Methods. The levels of both enzymes, from 80 GCF samples collected with PerioPaper strips, were analyzed by a Multiplex/Luminex assay. Five groups were formed, all current patients at the Institutional Dentistry Service, and distributed as follows: two groups of diabetics (one controlled and one poorly controlled); two groups with the previous conditions and diagnosed with POD2B; and one H group. Results. The highest concentration of MMP-9 corresponded to the H group, while the lowest corresponded to the T2D controlled group. Regarding MPO levels, the highest levels were associated with the T2D controlled with POD2B group and the lowest with the T2D controlled group. Conclusions. No apparent relationship between the elevation of MMP-9 and MPO levels was observed among subjects with T2D, with and without POD2B, compared to H subjects.

授权许可

Copyright © 2019 Diana C. Peniche-Palma et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Victor M. Martinez-Aguilar.Department of Specialization in Periodontology, Faculty of Dentistry, Autonomous University of Yucatan, Merida, Yucatan, ZIP 97000, Mexico, uady.mx;Basic Science Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, ZIP 78290, Mexico, uaslp.mx.victor.martinez@correo.uady.mx

推荐引用方式

Diana C. Peniche-Palma,Bertha A. Carrillo-Avila,Eduardo A. Sauri-Esquivel,Karla Acosta-Viana,Vicente Esparza-Villalpando,Amaury Pozos-Guillen,Marcela Hernandez-Rios,Victor M. Martinez-Aguilar. Levels of Myeloperoxidase and Metalloproteinase-9 in Gingival Crevicular Fluid from Diabetic Subjects with and without Stage 2, Grade B Periodontitis. BioMed Research International ,Vol.2019(2019)

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