首页 » 文章 » 文章详细信息
Natural Products and Bioprospecting Volume 8 ,Issue 6 ,2018-06-16
Synthesis and Cytotoxicities of Royleanone Derivatives
Short Communication
Cheng-Ji Li 1 , 2 Fan Xia 1 , 2 Rong Wu 3 Hong-Sheng Tan 3 Hong-Xi Xu 3 Gang Xu 1 Hong-Bo Qin 1
Show affiliations
DOI:10.1007/s13659-018-0173-y
Received 2018-5-13, accepted for publication 2018-6-8, Published 2018-6-8
PDF
摘要

Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.

关键词

para;Cytotoxicity;Royleanones

授权许可

© The Author(s) 2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

图表
通讯作者

1. Hong-Xi Xu.Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China.xuhongxi88@gmail.com
2. Gang Xu.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, 650201, Kunming, People’s Republic of China.xugang008@mail.kib.ac.cn
3. Hong-Bo Qin.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, 650201, Kunming, People’s Republic of China.qinhongbo@mail.kib.ac.cn

推荐引用方式

Cheng-Ji Li,Fan Xia,Rong Wu,Hong-Sheng Tan,Hong-Xi Xu,Gang Xu,Hong-Bo Qin. Synthesis and Cytotoxicities of Royleanone Derivatives. Natural Products and Bioprospecting ,Vol.8, Issue 6(2018)

您觉得这篇文章对您有帮助吗?
分享和收藏
0

是否收藏?

参考文献
[1] F Xia, CY Wu, XW Yang, X Li et al.Nat. Prod. Bioprospect.2015530731210.1007/s13659-015-0080-4
[2] K Miura, H Kikuzaki, N NakataniJ. Agr. Food. Chem.2002501845185110.1021/jf011314o
[3] XW Yang, X Deng, X Liu, CY Wu et al.Chem. Comm.2012485998600010.1039/c2cc32352d
[4] L Guasch, E Sala, M Mulero, C Valls et al.PLoS ONE20138e5588910.1371/journal.pone.0055889
[5] T Masuda, Y Oyama, T Arata, Y Inaba et al.Batt. New Tech. Med200233942
[6] OE Edwards, M Los, G FeniakCan. J. Chem.1962401540154610.1139/v62-232
[7] CY Wu, Y Liao, ZG Yang, XW Yang et al.Phytochemistry201410617117710.1016/j.phytochem.2014.07.001
[8] M Fronza, R Murillo, S Slusarczyk, M Adams et al.Bioorg. Med. Chem.2011194876488110.1016/j.bmc.2011.06.067
[9] I Chopra, J Kohli, K HandaIndian J. Med. Res.194533139141
[10] G Xu, AJ Hou, YT Zheng, Y Zhao et al.Org. Lett.2007929129310.1021/ol062748d
[11] JL Bolton, MA Trush, TM Penning, G Dryhurst et al.Chem. Res. Toxicol.20001313516010.1021/tx9902082
[12] D Ladeiras, CM Monteiro, F Pereira, CP Reis et al.Curr. Pharm. Design2016221682171410.2174/1381612822666151211094521
[13] MM Li, F Xia, CJ Li, G Xu et al.Tetrahedron Lett.201859464810.1016/j.tetlet.2017.11.046
[14] G Xu, AJ Hou, RR Wang, GY Liang et al.Org. Lett.200684453445610.1021/ol061609t
[15] G Majetich, S Liu, J Fang, D Siesel et al.J. Org. Chem.1997626928695110.1021/jo970570q
文献评价指标
浏览 29次
下载全文 4次
评分次数 0次
用户评分 0.0分
分享 0次
相关文章