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Natural Products and Bioprospecting Volume 8 ,Issue 5 ,2018-05-25
Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina
Original Article
Xiong-Wu Yang 1 , 2 Zhi Dai 3 , 2 Bei Wang 1 , 2 Ya-Ping Liu 1 , 4 Xu-Dong Zhao 3 Xiao-Dong Luo 1 , 4
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DOI:10.1007/s13659-018-0167-9
Received 2018-4-2, accepted for publication 2018-5-7, Published 2018-5-7
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摘要

The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China. As a part of our continuous effort to search for bioactive molecules from the plant, the fruits of A. marina were investigated, which has led to one new triterpenoid saponin (1) and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data. The new triterpenoid saponin showed cytotoxicity against GSC-3# and GSC-18# with the IC50 values were 12.21 and 5.53 μg/mL respectively, and most of the known compounds had significant antioxidant capacity with the IC50 values ranging from 0.36 to 13.07 μg/mL.

关键词

DPPH;GSCs;Triterpenoid saponin;Avicennia marina

授权许可

© The Author(s) 2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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通讯作者

1. Xu-Dong Zhao.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, People’s Republic of China.zhaoxudong@mail.kiz.ac.cn
2. Xiao-Dong Luo.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, People’s Republic of China;Yunnan Key Laboratory of Natural Medicinal Chemistry, 650201, Kunming, People’s Republic of China.xdluo@mail.kib.ac.cn

推荐引用方式

Xiong-Wu Yang,Zhi Dai,Bei Wang,Ya-Ping Liu,Xu-Dong Zhao,Xiao-Dong Luo. Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina. Natural Products and Bioprospecting ,Vol.8, Issue 5(2018)

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