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Natural Products and Bioprospecting Volume 8 ,Issue 4 ,2018-04-09
Antitumor Research on Artemisinin and Its Bioactive Derivatives
Review
Yunqin Zhang 1 , 2 Guowei Xu 1 , 2 Shuqun Zhang 1 Dong Wang 1 P. Saravana Prabha 1 Zhili Zuo 1 , 3
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DOI:10.1007/s13659-018-0162-1
Received 2018-1-9, accepted for publication 2018-3-27, Published 2018-3-27
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摘要

Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.Graphical Abstract

关键词

Mechanism;Activity;Antitumor;Artemisinin derivatives;Artemisinin

授权许可

© The Author(s) 2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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通讯作者

Zhili Zuo.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, China;Yunnan Key Laboratory of Natural Medicinal Chemistry, 650201, Kunming, Yunnan, China.zuozhili@mail.kib.ac.cn

推荐引用方式

Yunqin Zhang,Guowei Xu,Shuqun Zhang,Dong Wang,P. Saravana Prabha,Zhili Zuo. Antitumor Research on Artemisinin and Its Bioactive Derivatives. Natural Products and Bioprospecting ,Vol.8, Issue 4(2018)

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