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Natural Products and Bioprospecting Volume 8 ,Issue 3 ,2018-03-28
Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus
Original Article
Yang Tang 1 , 2 , 3 Zhen-Zhu Zhao 2 Zheng-Hui Li 2 Tao Feng 2 He-Ping Chen 2 Ji-Kai Liu 2
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DOI:10.1007/s13659-018-0160-3
Received 2018-2-14, accepted for publication 2018-3-26, Published 2018-3-26
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摘要

Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A–D (1–4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS spectroscopic analysis. Irpexoate B (2) displayed weak cytotoxicity against four human cancer cell lines (A-549, SMMC-7721, MCF-7, SW480) with IC50 values varying from 22.9 to 34.0 μM, and irpexoate D (4) showed weak cytotoxicity against the human cancer cell line SW480 with an IC50 value of 35.2 μM.Graphical Abstract

关键词

Cytotoxicity;Malonyl;Eburicane;Meruliaceae;Irpex lacteus

授权许可

© The Author(s) 2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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通讯作者

1. He-Ping Chen.School of Pharmaceutical Sciences, South-Central University for Nationalities, 430074, Wuhan, People’s Republic of China.chenhp@mail.scuec.edu.cn
2. Ji-Kai Liu.School of Pharmaceutical Sciences, South-Central University for Nationalities, 430074, Wuhan, People’s Republic of China.jkliu@mail.kib.ac.cn

推荐引用方式

Yang Tang,Zhen-Zhu Zhao,Zheng-Hui Li,Tao Feng,He-Ping Chen,Ji-Kai Liu. Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus. Natural Products and Bioprospecting ,Vol.8, Issue 3(2018)

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参考文献
[1] JH Ding, ZH Li, T Feng, JK Liu et al.Fitoterapia201812524524810.1016/j.fitote.2017.12.001
[2] JH Ding, T Feng, BK Cui, K Wei et al.Tetrahedron Lett.2013542651265410.1016/j.tetlet.2013.03.038
[3] HP Chen, ZZ Zhao, ZH Li, ZJ Dong et al.Chem. Open20165142149
[4] D SaggersonAnnu. Rev. Nutr.20082825327210.1146/annurev.nutr.28.061807.155434
[5] XM Dong, XH Song, KB Liu, CH Dong et al.Mycosystema2017362834
[6] HP Chen, JK LiuProg. Chem. Org. Nat. Prod.2017106120110.1007/978-3-319-59542-9_1
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