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FOOD AND AGRICULTURAL IMMUNOLOGY Volume 29 ,Issue 1 ,2018-01-01
Effects of glutamate and aspartate on growth performance, serum amino acids, and amino acid transporters in piglets
Original Articles
Yuying Li 1 , 2 , 3 , 4 , 5 Hui Han 1 , 2 , 3 , 4 , 5 Jie Yin 1 , 2 , 3 , 4 , 5 Jie Zheng 6 Xiaotong Zhu 7 Tiejun Li 1 , 2 , 3 , 4 , 8 Yulong Yin 1 , 2 , 3 , 4 , 8
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DOI:10.1080/09540105.2018.1437892
Received 2017-12-19, accepted for publication 2018-2-3, Published 2018-2-3
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摘要

This study mainly investigated the effects of different dietary levels of glutamate (Glu) and aspartate (Asp) on growth performance, blood amino acids, and amino acid transporters in piglets. Forty-two healthy piglets were randomly divided into six groups (n = 7): a control group in which piglets were fed 2.9% Glu and 1.5% Asp and other groups in which piglets received 1.3% or 1.7% Asp and 2.6%, 3.2%, or 3.5% Glu for 21 days. Growth performance, serum amino acid profiles from the mesenteric vein, portal vein, and anterior vena cava, and amino acid transporters in the liver were determined. The results showed that lower doses of Asp promoted growth and enhanced the amino acids, while high doses of Asp and Glu reduced growth and the amino acid pool in piglets (P < 0.05). Meanwhile, 3.2% Glu increased branched chain amino acids in the portal vein and anterior vena cava (P < 0.05). 3.5% Glu downregulated SLC7A1, SLC7A7, and SLC6A19 expression in the liver (P < 0.05). Collectively, these results indicated that different dietary doses of Glu and Asp influenced growth performance and serum amino acid.Abbreviations: Ala: alanine; Arg: arginine; Asp: aspartate; ADFI: average daily feed intake; ADG: average daily gain; Cys: cystine; F/G: feed intake/gain; Glu: glutamate; Gly: glycine; His: histidine; Ile: isoleucine; Leu: leucine; Lys: lysine; Met: methionine; Phe: phenylalanine; Pro: proline; Ser: serine; TAA: total amino acid; Thr: threonine; Try: tryptophan; Tyr: tyrosine; Val: valine; SLC1A1: solute carrier family 1 member 1; SLC7A1: solute carrier family 7 member 1; SLC7A7: solute carrier family7 member 7; SLC6A19: solute carrier family 6 member 19

关键词

amino acid transporters;amino acid;aspartate;glutamate;Piglets

授权许可

© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

图表

Effects of dietary Asp (A, B, C, D) and Glu (E, F, G, H) on amino acid transporters in the liver. Data are presented as mean ± SEM, n = 6. SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system XAG, member 1), SLC7A1 solute carrier family 7 (cationic amino acid transporter, y + system; member 1), SLC7A7 solute carrier family7 (amino acid transporter light chain, y + L system, member 7), and SLC6A19 solute carrier family 6 (neurotransmitter/neutral amino acid transporter, member 19).

通讯作者

1. Tiejun Li.Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, People's Republic of Chin;National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, Hunan, People's Republic of Chin;Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, People's Republic of Chin;Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, People's Republic of Chin;Hunan Co-Innovation Center of Animal Production Safety, Changsha, Hunan, People's Republic of Chin.tjli@isa.ac.cn
2. Yulong Yin.Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, People's Republic of Chin;National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, Hunan, People's Republic of Chin;Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, People's Republic of Chin;Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, People's Republic of Chin;Hunan Co-Innovation Center of Animal Production Safety, Changsha, Hunan, People's Republic of Chin.yinyulong@isa.ac.cn

推荐引用方式

Yuying Li,Hui Han,Jie Yin,Jie Zheng,Xiaotong Zhu,Tiejun Li,Yulong Yin. Effects of glutamate and aspartate on growth performance, serum amino acids, and amino acid transporters in piglets. FOOD AND AGRICULTURAL IMMUNOLOGY ,Vol.29, Issue 1(2018)

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