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Evidence-Based Complementary and Alternative Medicine Volume 2019 ,2019-03-04
Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr
Research Article
Fenfen Wei 1 Qinghua He 1 Wenjuan Wang 1 Dong Pei 2 Bo Zhang 1
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DOI:10.1155/2019/9819643
Received 2018-12-11, accepted for publication 2019-02-11, Published 2019-02-11
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摘要

Cynomorium songaricum Rupr, known as Suo Yang, is most commonly used to treat fatigue, protect the liver, and invigorate kidneys in Northwest China. Given the wide medicinal utilisation and lack of safety evaluation, this work evaluated the acute toxicity, genetic toxicity, and 90-day repeated oral toxicity of Suo Yang. Twenty Kunming mice were orally given Suo Yang once and observed for 14 days in the acute toxicity test. The genetic toxicity of Suo Yang was tested using in vivo and vitro assays (bacterial reverse mutation test, mouse bone marrow micronucleus assay, and spermatocyte chromosomal aberration assay). In the 90-day repeated oral toxicity study, 80 SD rats were randomly divided into 4 groups and then orally given Suo Yang at different concentrations (1.04, 2.08 or 4.16 g/kg), while the control group was given sterile water. In the acute toxicity test, no abnormal behaviour or mortality was found in mice. The results suggest that the maximum tolerable dose of Suo Yang is greater than 15 g/kg. In the genotoxicity studies, no revertant colonies were produced in vitro. In the in vivo assays, no increased frequencies of micronuclei or structural abnormalities of spermatocyte chromosomes were found. In the 90-day repeated oral toxicity study, no significant toxicological manifestations were observed in haematological parameters or clinical and pathological examinations. In summary, these results suggest that Suo Yang at the given doses does not cause adverse effects in animals. Thus, Suo Yang can reasonably be considered a safe herbal medicine.

授权许可

Copyright © 2019 Fenfen Wei et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Bo Zhang.Beijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing, China, buu.edu.cn.zhangbo_wl@buu.edu.cn

推荐引用方式

Fenfen Wei,Qinghua He,Wenjuan Wang,Dong Pei,Bo Zhang. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr. Evidence-Based Complementary and Alternative Medicine ,Vol.2019(2019)

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