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Stem Cells International Volume 2019 ,2019-01-15
Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair
Review Article
Ihsène Taïhi 1 , 2 Ali Nassif 1 , 3 , 4 , 5 Juliane Isaac 1 Benjamin Philippe Fournier 1 , 6 François Ferré 1 , 2
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Received 2018-07-04, accepted for publication 2018-12-06, Published 2018-12-06

A large array of therapeutic procedures is available to treat cartilage disorders caused by trauma or inflammatory disease. Most are invasive and may result in treatment failure or development of osteoarthritis due to extensive cartilage damage from repeated surgery. Despite encouraging results of early cell therapy trials that used chondrocytes collected during arthroscopic surgery, these approaches have serious disadvantages, including morbidity associated with cell harvesting and low predictive clinical outcomes. To overcome these limitations, adult stem cells derived from bone marrow and subsequently from other tissues are now considered as preferred sources of cells for cartilage regeneration. Moreover, with new evidence showing that the choice of cell source is one of the most important factors for successful cell therapy, there is growing interest in neural crest-derived cells in both the research and clinical communities. Neural crest-derived cells such as nasal chondrocytes and oral stem cells that exhibit chondrocyte-like properties seem particularly promising in cartilage repair. Here, we review the types of cells currently available for cartilage cell therapy, including articular chondrocytes and various mesenchymal stem cells, and then highlight recent developments in the use of neural crest-derived chondrocytes and oral stem cells for repair of cartilage lesions.


Copyright © 2019 Ihsène Taïhi et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ali Nassif.Laboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, Universites of Paris-Descartes, Pierre and Marie Curie and Paris-Diderot, 15 rue de l’école de médecine, Paris, France, inserm.fr;AP-HP, Bretonneau Hospital, Dental Department, Paris 75018, France, aphp.fr;Mondor Institute for Biomedical Research (IMRB), INSERM U955, Team 5, Faculty of Medicine, University of Paris-EST, Créteil, France, inserm.fr;Laboratory of Pharmacology of Cerebral Circulation, EA4475, Faculty of Pharmacy, University of Paris Descartes, France, univ-paris5.fr.dent4world@gmail.com


Ihsène Taïhi,Ali Nassif,Juliane Isaac,Benjamin Philippe Fournier,François Ferré. Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair. Stem Cells International ,Vol.2019(2019)



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