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Journal of Toxicology Volume 2019 ,2019-01-17
Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats
Research Article
Srinivasa Reddy Jitta 1 Prasanthi Daram 1 Karthik Gourishetti 2 C. S. Misra 2 Picheswara Rao Polu 1 Abhishek Shah 1 C. S. Shreedhara 1 Madhavan Nampoothiri 2 Richard Lobo 1
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DOI:10.1155/2019/7898914
Received 2018-05-29, accepted for publication 2018-12-10, Published 2018-12-10
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摘要

Terminalia tomentosa bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of T. tomentosa bark confirms the presence of flavonoids, polyphenols, and tannins. The plant has not been investigated for its anti-inflammatory and antiarthritic activity. The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity. Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods. In vivo antiarthritic potential of the extracts was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar rats. Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund’s Adjuvant-induced arthritis in Wistar rats. This study shows that the T. tomentosa bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of T. tomentosa.

授权许可

Copyright © 2019 Srinivasa Reddy Jitta et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Richard Lobo.Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India, manipal.edu.avemaria_lobo@yahoo.com

推荐引用方式

Srinivasa Reddy Jitta,Prasanthi Daram,Karthik Gourishetti,C. S. Misra,Picheswara Rao Polu,Abhishek Shah,C. S. Shreedhara,Madhavan Nampoothiri,Richard Lobo. Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats. Journal of Toxicology ,Vol.2019(2019)

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