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Journal of Nanomaterials Volume 2019 ,2019-01-15
Lipid Nano- and Microparticles: An Overview of Patent-Related Research
Review Article
Luigi Battaglia 1 Elena Ugazio 1
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DOI:10.1155/2019/2834941
Received 2018-08-25, accepted for publication 2018-11-25, Published 2018-11-25
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摘要

The traits of lipid biocompatibility and versatility have led to many nano- and microparticulate lipid formulations being engineered, over the last two decades, in the form of spheres and capsules, using solid and liquid lipids as the matrices. This review describes the main types of lipid nano- and microparticles, as well as their preparation methods, administration routes, and main fields of application. It will also provide a synthetic overview of the main patents that have been filed. Patenting activity in the lipid nanoparticle field has been ongoing for 25 years and has been driven by the boom in the use of nanotechnology as an innovative tool for disease treatment and potential commercial interest in a fully biocompatible vehicle. Initially, activity was mainly focused on technological aspects, and later focus shifted more to usage and composition. An increasing number of patents are also being filed by Emerging Countries. However, the most important limitation here is the low number of marketed products, which is mainly caused by regulatory restrictions and economic reasons.

授权许可

Copyright © 2019 Luigi Battaglia and Elena Ugazio. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Luigi Battaglia.Università degli Studi di Torino-Dipartimento di Scienza e Tecnologia del Farmaco, via Pietro Giuria 9, Turin, Italy, unito.it.luigi.battaglia@unito.it

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Luigi Battaglia,Elena Ugazio. Lipid Nano- and Microparticles: An Overview of Patent-Related Research. Journal of Nanomaterials ,Vol.2019(2019)

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