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Mediators of Inflammation Volume 2019 ,2019-01-10
CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice
Research Article
Kang Wu 1 , 2 , 3 Fei Wang 1 , 2 Guangwu Guo 2 Yuqing Li 2 , 3 Li-Jun Qiu 4 Xuefeng Li 2 , 3
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Received 2018-08-26, accepted for publication 2018-10-31, Published 2018-10-31

The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122high stem cell antigen-1 (Sca-1) high B cell lymphoma 2 (Bcl-2) high CD4+ stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorously to blood-borne antigens. Interestingly, the natural CD4+ TSCMs homing to the BM colocalized with VCAM-1+ IL-15+ IL-7+ CXCL-12+ stromal cells. Furthermore, compared to spleen-resident CD4+ TSCMs, BM-resident TSCMs induced the production of high-affinity antibodies against influenza by B lymphocytes more efficiently. Taken together, these observations indicate that the BM provides an appropriate microenvironment for the survival of CD4+ TSCMs, which broadens our knowledge regarding the memory maintenance of antigen-specific CD4+ T lymphocytes.


Copyright © 2019 Kang Wu et al. 2019
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


1. Li-Jun Qiu.Department of Neurology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China, hust.edu.cn.13476164215@163.com
2. Xuefeng Li.Shenzhen Luohu People’s Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518001, China, szu.edu.cn;Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, cas.cn.xuefengli@gzhmu.edu.cn


Kang Wu,Fei Wang,Guangwu Guo,Yuqing Li,Li-Jun Qiu,Xuefeng Li. CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice. Mediators of Inflammation ,Vol.2019(2019)



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