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Journal of Diabetes Research Volume 2018 ,2018-12-30
Two-Year Changes in Hyperuricemia and Risk of Diabetes: A Five-Year Prospective Cohort Study
Research Article
Jia Liu 1 , 2 Lixin Tao 1 , 2 Zhan Zhao 3 , 4 Yongmin Mu 5 Dechun Zou 6 Jingbo Zhang 7 Xiuhua Guo 1 , 2
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DOI:10.1155/2018/6905720
Received 2018-08-12, accepted for publication 2018-11-27, Published 2018-11-27
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摘要

Background. Hyperuricemia is known to be a risk factor for diabetes. However, information is limited regarding the association between changes in hyperuricemia and the risk of diabetes. Methods. A total of 15,403 participants who were free of diabetes at the time of 2009 and 2011 surveys in the Beijing Health Management Cohort (BHMC) study were recruited and followed up until 2016. Participants were classified into four groups according to 2-year changes in hyperuricemia: no hyperuricemia, remittent hyperuricemia, incident hyperuricemia, and persistent hyperuricemia. Modified Poisson regression models were used to evaluate the effect of 2-year changes in hyperuricemia on the risk of diabetes. Results. During the 5-year follow-up, we identified 841 new cases of diabetes (216 women). Remittent hyperuricemia and incident hyperuricemia had a 35% and 48% higher risk for developing diabetes compared with no hyperuricemia. Especially, persistent hyperuricemia was associated with a 75% higher risk of diabetes (RR = 1.75, 95% CI = 1.47-2.08). Compared with minor serum uric acid (SUA) change, over 10% decline and over 30% increase in SUA levels were subsequently associated with lower (RR = 0.84, 95% CI = 0.72-0.99) and higher (RR = 1.71, 95% CI = 1.27-2.30) diabetes risk, respectively. Conclusions. Changes in hyperuricemia, especially persistent hyperuricemia, are more appropriate to reflect the risk of diabetes than a single measurement of hyperuricemia at baseline. Strategies aiming at preventing hyperuricemia are urgently needed to reduce the increasing burden of diabetes.

授权许可

Copyright © 2018 Jia Liu et al. 2018
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Xiuhua Guo.School of Public Health, Capital Medical University, Beijing, China, ccmu.edu.cn;Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.statguo@ccmu.edu.cn

推荐引用方式

Jia Liu,Lixin Tao,Zhan Zhao,Yongmin Mu,Dechun Zou,Jingbo Zhang,Xiuhua Guo. Two-Year Changes in Hyperuricemia and Risk of Diabetes: A Five-Year Prospective Cohort Study. Journal of Diabetes Research ,Vol.2018(2018)

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