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Microbial Biotechnology Volume 12 ,Issue 1 ,2018-12-19
Unlocking the potential of natural products in drug discovery
Crystal Ball
Gerard D. Wright 1
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DOI:10.1111/1751-7915.13351
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摘要

The natural product specialized metabolites produced by microbes and plants are the backbone of our current drugs. Despite their historical importance, few pharmaceutical companies currently emphasize their exploitation in new drug discovery and instead favour synthetic compounds as more tractable alternatives. Ironically, we are in a Golden Age of understanding of natural product biosynthesis, biochemistry and engineering. These advances have the potential to usher in a new era of natural product exploration and development taking full advantage of the unique and favourable properties of natural products compounds in drug discovery.

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© 2019 John Wiley & Sons Ltd and Society for Applied Microbiology
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

通讯作者

Gerard D. Wright.M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.wrightge@mcmaster.ca

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Gerard D. Wright. Unlocking the potential of natural products in drug discovery. Microbial Biotechnology ,Vol.12, Issue 1(2018)

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