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BioMed Research International Volume 2017 ,2017-12-28
Antifungal Compounds against Candida Infections from Traditional Chinese Medicine
Review Article
Xin Liu 1 Zhiming Ma 2 Jingxiao Zhang 3 Longfei Yang 4
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DOI:10.1155/2017/4614183
Received 2017-08-25, accepted for publication 2017-12-06, Published 2017-12-06
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摘要

Infections caused by Candida albicans, often refractory and with high morbidity and mortality, cause a heavy burden on the public health while the current antifungal drugs are limited and are associated with toxicity and resistance. Many plant-derived molecules including compounds isolated from traditional Chinese medicine (TCM) are reported to have antifungal activity through different targets such as cell membrane, cell wall, mitochondria, and virulence factors. Here, we review the recent progress in the anti-Candida compounds from TCM, as well as their antifungal mechanisms. Considering the diverse targets and structures, compounds from TCM might be a potential library for antifungal drug development.

授权许可

Copyright © 2017 Xin Liu et al. 2017
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Longfei Yang.Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, China, jlu.edu.cn.yanglongfei@jlu.edu.cn

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Xin Liu,Zhiming Ma,Jingxiao Zhang,Longfei Yang. Antifungal Compounds against Candida Infections from Traditional Chinese Medicine. BioMed Research International ,Vol.2017(2017)

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