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BioMed Research International Volume 2017 ,2017-10-24
Punctaporonins N–S, New Caryophyllene Sesquiterpenoids from Cytospora sp.
Research Article
Yan Li 1 , 2 Qingbin Wang 1 Xingzhong Liu 3 Yongsheng Che 1
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DOI:10.1155/2017/7871459
Received 2017-05-05, accepted for publication 2017-08-22, Published 2017-08-22
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摘要

Six new caryophyllene sesquiterpenoids, punctaporonins N–S (1–6), and three known ones, 6-hydroxypunctaporonins B (7), A (8), and E (9), have been isolated from solid cultures of Cytospora sp. The structures of 1–6 were elucidated primarily by NMR spectroscopy. The absolute configuration of 1 was assigned by X-ray crystallographic analysis of its S-MTPA ester. Compounds 2, 5, and 6 showed modest cytotoxicity against HeLa cells.

授权许可

Copyright © 2017 Yan Li et al. 2017
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

图表

Structures of compounds 1–9.

Key NOESY correlations for punctaporonin N (1).

Thermal ellipsoid representation of 1a.

通讯作者

Yongsheng Che.State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China.cheys@im.ac.cn

推荐引用方式

Yan Li,Qingbin Wang,Xingzhong Liu,Yongsheng Che. Punctaporonins N–S, New Caryophyllene Sesquiterpenoids from Cytospora sp.. BioMed Research International ,Vol.2017(2017)

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