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PPAR Research Volume 2017 ,2017-07-27
Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids
Review Article
Qiansheng Huang 1 , 2 Qionghua Chen 3
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DOI:10.1155/2017/3203161
Received 2017-03-31, accepted for publication 2017-06-21, Published 2017-06-21
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摘要

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that are widely involved in various physiological functions. They are widely expressed through the reproductive system. Their roles in the metabolism and function of sex steroids and thus the etiology of reproductive disorders receive great concern. Various kinds of exogenous chemicals, especially environmental pollutants, exert their adverse impact on the reproductive system through disturbing the PPAR signaling pathway. Chemicals could bind to PPARs and modulate the transcription of downstream genes containing PPRE (peroxisome proliferator response element). This will lead to altered expression of genes related to metabolism of sex steroids and thus the abnormal physiological function of sex steroids. In this review, various kinds of environmental ligands are summarized and discussed. Their interactions with three types of PPARs are classified by various data from transcript profiles, PPRE reporter in cell line, in silico docking, and gene silencing. The review will contribute to the understanding of the roles of PPARs in the reproductive toxicology of environmental chemicals.

授权许可

Copyright © 2017 Qiansheng Huang and Qionghua Chen. 2017
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Qiansheng Huang.Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China, cas.cn;Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China, cas.cn.qshuang@iue.ac.cn

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Qiansheng Huang,Qionghua Chen. Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids. PPAR Research ,Vol.2017(2017)

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