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BioMed Research International Volume 2017 ,2017-07-24
L-Theanine Administration Modulates the Absorption of Dietary Nutrients and Expression of Transporters and Receptors in the Intestinal Mucosa of Rats
Research Article
Qiongxian Yan 1 , 2 Haiou Tong 2 Shaoxun Tang 1 , 3 Zhiliang Tan 1 , 3 Xuefeng Han 1 , 2 Chuanshe Zhou 1 , 3
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DOI:10.1155/2017/9747256
Received 2017-03-20, accepted for publication 2017-06-15, Published 2017-06-15
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摘要

L-theanine has various advantageous functions for human health; whether or not it could mediate the nutrients absorption is unknown yet. The effects of L-theanine on intestinal nutrients absorption were investigated using rats ingesting L-theanine solution (0, 50, 200, and 400 mg/kg body weight) per day for two weeks. The decline of insulin secretion and glucose concentration in the serum was observed by L-theanine. Urea and high-density lipoprotein were also reduced by 50 mg/kg L-theanine. Jejunal and ileac basic amino acids transporters SLC7a1 and SLC7a9, neutral SLC1a5 and SLC16a10, and acidic SLC1a1 expression were upregulated. The expression of intestinal SGLT3 and GLUT5 responsible for carbohydrates uptake and GPR120 and FABP2 associated with fatty acids transport were inhibited. These results indicated that L-theanine could inhibit the glucose uptake by downregulating the related gene expression in the small intestine of rats. Intestinal gene expression of transporters responding to amino acids absorption was stimulated by L-theanine administration.

授权许可

Copyright © 2017 Qiongxian Yan et al. 2017
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Zhiliang Tan.Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Research Center of Livestock & Poultry Sciences, South-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of Agriculture, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan 410125, China, cas.cn;Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, China.zltan@isa.ac.cn

推荐引用方式

Qiongxian Yan,Haiou Tong,Shaoxun Tang,Zhiliang Tan,Xuefeng Han,Chuanshe Zhou. L-Theanine Administration Modulates the Absorption of Dietary Nutrients and Expression of Transporters and Receptors in the Intestinal Mucosa of Rats. BioMed Research International ,Vol.2017(2017)

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