首页 » 文章 » 文章详细信息
Journal of Nutrition and Metabolism Volume 2017 ,2017-07-11
Inflammatory Markers Are Positively Associated with Serum trans-Fatty Acids in an Adult American Population
Research Article
Mohsen Mazidi 1 , 2 Hong-kai Gao 3 Andre Pascal Kengne 4
Show affiliations
DOI:10.1155/2017/3848201
Received 2017-03-09, accepted for publication 2017-05-24, Published 2017-05-24
PDF
摘要

Background and Aim. The relationship between serum trans-fatty acids (TFAs) and systemic inflammation markers is unclear. We investigated the association of serum TFAs with high sensitivity C-reactive protein (hs-CRP) and fibrinogen in adult Americans. Methods. The 1999 to 2000 National Health and Nutrition Examination Survey (NHANES) participants with measured data on hs-CRP and fibrinogen were included. TFAs were measured via capillary gas chromatography and mass spectrometry using negative chemical ionization. Analysis of covariance and multivariable-adjusted linear regression models were used to investigate the associations between these parameters, accounting for the survey design. Results. Of the 5446 eligible participants, 46.8% (n=2550) were men. The mean age was 47.1 years overall: 47.8 years in men and 46.5 years in women (p=0.085). After adjustment for age and sex, mean serum TFAs rose with the increasing quarters of hs-CRP and fibrinogen (both p<0.001). In linear regression models adjusted for age, sex, race, education, marital status, body mass index, and smoking, serum TFAs were an independent predictor of plasma hs-CRP and fibrinogen levels. Conclusion. A high level of TFAs appears to be a contributor to an unfavourable inflammatory profile. Because serum TFAs concentrations are affected by dietary TFA intake, these data suggest a possible contribution of TFAs intake modulation in the prevention of inflammation-related chronic diseases.

授权许可

Copyright © 2017 Mohsen Mazidi et al. 2017
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

通讯作者

Mohsen Mazidi.Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China, cas.cn;Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Sciences (IC-UCAS), West Beichen Road, Chaoyang, China, ucas.ac.cn.moshen@genetics.ac.cn

推荐引用方式

Mohsen Mazidi,Hong-kai Gao,Andre Pascal Kengne. Inflammatory Markers Are Positively Associated with Serum trans-Fatty Acids in an Adult American Population. Journal of Nutrition and Metabolism ,Vol.2017(2017)

您觉得这篇文章对您有帮助吗?
分享和收藏
5

是否收藏?

参考文献
[1] M. Mazidi, S. Pennathur, F. Afshinnia. (2017). Link of dietary patterns with metabolic syndrome: analysis of the national health and nutrition examination survey. Nutrition & Diabetes.7(3):e255. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[2] M. Mazidi, A. P. Kengne. (2017). Nutrient patterns and their relationship with general and central obesity in US adults. European Journal of Clinical Investigation. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[3] M. Mazidi, A. P. Kengne, A. Sahebkar, M. Banach. et al.(2017). Telomere length is associated with cardiometabolic factors in US adults. Angiology. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[4] M. Mazidi, P. Penson, M. Banach. (2017). Association between telomere length and complete blood count in US adults. Archives of Medical Science.13(3):601-605. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[5] M. Mazidi, A. P. Kengne, D. P. Mikhailidis, A. F. Cicero. et al.(2017). Effects of selected dietary constituents on high-sensitivity C-reactive protein levels in U.S. adults. Annals of Medicine:1-6. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[6] J. R. Benatar, R. A. Stewart. (2014). The effects of changing dairy intake on trans and saturated fatty acid levels- results from a randomized controlled study. Nutrition Journal.13(1, article 32). DOI: 10.1161/01.CIR.0000089190.95415.9F.
[7] P. J. Nestel, N. Straznicky, N. A. Mellett, G. Wong. et al.(2014). Specific plasma lipid classes and phospholipid fatty acids indicative of dairy food consumption associate with insulin sensitivity. American Journal of Clinical Nutrition.99(1):46-53. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[8] S. A. Bingham, R. Luben, A. Welch, N. Wareham. et al.(2003). Are imprecise methods obscuring a relation between fat and breast cancer?. Lancet.362(9379):212-214. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[9] . DOI: 10.1161/01.CIR.0000089190.95415.9F.
[10] M. Mazidi, E. Karimi, P. Rezaie, G. A. Ferns. et al.(2017). Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Journal of Diabetes and Its Complications.31(7):1237-1242. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[11] M. S. Butt, M. T. Sultan. (2009). Levels of trans fats in diets consumed in developing economies. Journal of AOAC International.92(5):1277-1283. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[12] M. Saadatian-Elahi, N. Slimani, V. Chajès, M. Jenab. et al.(2009). Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition.89(1):331-346. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[13] M. Sommerfeld. (1983). Trans unsaturated fatty acids in natural products and processed foods. Progress in Lipid Research.22(3):221-233. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[14] D. Mozaffarian, M. Abdollahi, H. Campos, A. HoushiarRad. et al.(2007). Consumption of trans fats and estimated effects on coronary heart disease in Iran. European Journal of Clinical Nutrition.61(8):1004-1010. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[15] K. Kondo, T. Ishida, T. Yasuda, H. Nakajima. et al.(2015). Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors. Molecular Nutrition and Food Research.59(4):729-740. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[16] V. Chajès, A. C. M. Thiébaut, M. Rotival, E. Gauthier. et al.(2008). Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC study. American Journal of Epidemiology.167(11):1312-1320. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[17] J. Petaja. (2011). Inflammation and coagulation. An overview. Thrombosis Research.127:S34-S37. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[18] S. M. Innis, T. J. Green, T. K. Halsey. (1999). Variability in the trans fatty acid content of foods within a food category: Implications for estimation of dietary trans fatty acid intakes. Journal of the American College of Nutrition.18(3):255-260. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[19] D. Mozaffarian, T. Pischon, S. E. Hankinson, N. Rifai. et al.(2004). Dietary intake of trans fatty acids and systemic inflammation in women. American Journal of Clinical Nutrition.79(4):606-612. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[20] D. Mozaffarian, M. C. De Oliveira Otto, R. N. Lemaitre, A. M. Fretts. et al.(2013). Trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the multi-ethnic study of atherosclerosis (MESA). American Journal of Clinical Nutrition.97(4):854-861. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[21] D. Mozaffarian, H. Cao, I. B. King, R. N. Lemaitre. et al.(2010). Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Annals of Internal Medicine.153(12):790-799. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[22] E. Lopez-Garcia, M. B. Schulze, J. B. Meigs. (2005). Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. Journal of Nutrition.135(3):562. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[23] . DOI: 10.1161/01.CIR.0000089190.95415.9F.
[24] S. P. Caudill, R. L. Schleicher, J. L. Pirkle. (2008). Multi-rule quality control for the age-related eye disease study. Statistics in Medicine.27(20):4094-4106. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[25] A. Baylin, H. Campos. (2006). The use of fatty acid biomarkers to reflect dietary intake. Current Opinion in Lipidology.17(1):22-27. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[26] J. Monteiro, M. Leslie, M. H. Moghadasian, B. M. Arendt. et al.(2014). The role of - 6 and - 3 polyunsaturated fatty acids in the manifestation of the metabolic syndrome in cardiovascular disease and non-alcoholic fatty liver disease. Food & Function.5(3):426-435. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[27] M. Mazidi, E. D. Michos, M. Banach. (2017). The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey. Archives of Medical Science.13(1):61-65. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[28] H. Y. Lee, J. Woo, Z. Y. Chen, S. F. Leung. et al.(2000). Serum fatty acid, lipid profile and dietary intake of Hong Kong Chinese omnivores and vegetarians. European Journal of Clinical Nutrition.54(10):768-773. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[29] National Center for Health Statistics. National Health and NutritionExamination Survey (NHANES). Questionnaires, datasets, and related documentation. . DOI: 10.1161/01.CIR.0000089190.95415.9F.
[30] A. Baylin, K. K. Mi, A. Donovan-Palmer, X. Siles. et al.(2005). Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: comparison with adipose tissue and plasma. American Journal of Epidemiology.162(4):373-381. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[31] D. J. Baer, J. T. Judd, B. A. Clevidence, R. P. Tracy. et al.(2004). Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. The American Journal of Clinical Nutrition.79(6):969-973. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[32] P. E. Szmitko, C.-H. Wang, R. D. Weisel, J. R. de Almeida. et al.(2003). New markers of inflammation and endothelial cell activation Part I. Circulation.108(16):1917-1923. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[33] M. N. Richard, R. Ganguly, S. N. Steigerwald, A. Al-Khalifa. et al.(2007). Dietary hempseed reduces platelet aggregation. Journal of Thrombosis and Haemostasis.5(2):424-425. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[34] F. K. Welty, A. Alfaddagh, T. K. Elajami. (2016). Targeting inflammation in metabolic syndrome. Translational Research.167(1):257-280. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[35] V. Chajès, C. Biessy, G. Byrnes, G. Deharveng. et al.(2011). Ecological-Level associations between highly processed food intakes and plasma phospholipid elaidic acid concentrations: results from a cross-sectional study within the European prospective investigation into Cancer and nutrition (EPIC). Nutrition and Cancer.63(8):1235-1250. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[36] M. B. Pepys, G. M. Hirschfield. (2003). C-reactive protein: a critical update. Journal of Clinical Investigation.111(12):1805-1812. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[37] J. Ma, A. R. Folsom, J. H. Eckfeldt, L. Lewis. et al.(1995). Short- and long-term repeatability of fatty acid composition of human plasma phospholipids and cholesterol esters. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. American Journal of Clinical Nutrition.62(3):572-578. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[38] N. T. Bendsen, S. Stender, P. B. Szecsi, S. B. Pedersen. et al.(2011). Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women. Journal of Lipid Research.52(10):1821-1828. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[39] (2015). Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys. BMJ.350, article h1702. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[40] V. Chajès, C. Biessy, P. Ferrari, I. Romieu. et al.(2015). Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: report from the EPIC study. PLoS ONE.10(2). DOI: 10.1161/01.CIR.0000089190.95415.9F.
[41] W. C. Willett, M. J. Stampfer, J. E. Manson, G. A. Colditz. et al.(1993). Intake of trans fatty acids and risk of coronary heart disease among women. The Lancet.341(8845):581-585. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[42] D. Mozaffarian. (2016). Natural trans fat, dairy fat, partially hydrogenated oils, and cardiometabolic health: The Ludwigshafen Risk and Cardiovascular Health Study. European Heart Journal.37(13):1079-1081. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[43] M. Mazidi, A. Heidari-Bakavoli, S. S. Khayyatzadeh, M. R. Azarpazhooh. et al.(2016). Serum hs-CRP varies with dietary cholesterol, but not dietary fatty acid intake in individuals free of any history of cardiovascular disease. European Journal of Clinical Nutrition.70(12):1454-1457. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[44] J. E. Enns, A. Yeganeh, R. Zarychanski, A. M. Abou-Setta. et al.(2014). The impact of omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: a systematic review and meta-analysis. BMC Cardiovascular Disorders.14, article 70. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[45] D. Mozaffarian, M. B. Katan, A. Ascherio, M. J. Stampfer. et al.(2006). Trans fatty acids and cardiovascular disease. New England Journal of Medicine.354(15):1601-1613. DOI: 10.1161/01.CIR.0000089190.95415.9F.
[46] K. A. Harvey, C. L. Walker, Z. Xu, P. Whitley. et al.(2012). Trans fatty acids: Induction of a pro-inflammatory phenotype in endothelial cells. Lipids.47(7):647-657. DOI: 10.1161/01.CIR.0000089190.95415.9F.
文献评价指标
浏览 56次
下载全文 9次
评分次数 0次
用户评分 0.0分
分享 5次