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Bioinorganic Chemistry and Applications Volume 2017 ,2017-03-08
Hazardous Effects of Titanium Dioxide Nanoparticles in Ecosystem
Review Article
Syed Niaz Ali Shah 1 , 2 Zahir Shah 3 , 4 Muzammal Hussain 3 Muzaffar Khan 4
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DOI:10.1155/2017/4101735
Received 2016-12-23, accepted for publication 2017-02-08, Published 2017-02-08
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摘要

Although nanoparticles (NPs) have made incredible progress in the field of nanotechnology and biomedical research and their applications are demanded throughout industrial world particularly over the past decades, little is known about the fate of nanoparticles in ecosystem. Concerning the biosafety of nanotechnology, nanotoxicity is going to be the second most priority of nanotechnology that needs to be properly addressed. This review covers the chemical as well as the biological concerns about nanoparticles particularly titanium dioxide (TiO2) NPs and emphasizes the toxicological profile of TiO2 at the molecular level in both in vitro and in vivo systems. In addition, the challenges and future prospects of nanotoxicology are discussed that may provide better understanding and new insights into ongoing and future research in this field.

授权许可

Copyright © 2017 Syed Niaz Ali Shah et al. 2017
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

图表

Nanoparticles containing products and their entrance ways into the biological system.

Nano-TiO2-induced NETosis cell death pathway.

The apoptosis induced by TiO2 NPs. The TiO2 NPs-induced apoptosis mostly follows the intrinsic pathway. TiO2 NPs enter the cell, induce ROS generation, and then enter the nucleus causing DNA damage. The DNA damage is sensed by sensor proteins (ATM/ATR) as a consequence of which p53 is upregulated, which further activates Bax (promoter of apoptosis) and inhibits Bcl2 (inhibitor of Bax).

Nano-TiO2-induced tissue injury and inflammation. These NPs cause elevation of ROS, decline of GSH levels, inhibition of PMN apoptosis, and tyrosine phosphorylation of p38MAPK and ERK1/2 or JNK. All these induce the production of different inflammatory cytokines that in turn lead to inflammation and consequent necrosis or apoptosis mechanism of cell death. Decreased detoxification due to CYP1A and HSP70 decline also leads to tissue injury or cell death.

通讯作者

1. Syed Niaz Ali Shah.Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk;Department of Chemistry, Tsinghua University, Beijing 100084, China, tsinghua.edu.cn.niazalianalyst@gmail.com
2. Zahir Shah.Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, China, cas.cn;Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.zahir@gibh.ac.cn

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Syed Niaz Ali Shah,Zahir Shah,Muzammal Hussain,Muzaffar Khan. Hazardous Effects of Titanium Dioxide Nanoparticles in Ecosystem. Bioinorganic Chemistry and Applications ,Vol.2017(2017)

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